SCHEMBL66295

SCHEMBL66295

Clc1nc2c(Cl)cccc2[nH]1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 4/20 0.59
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
ADORA1 P30542 2/20 0.49
ADORA3 P0DMS8 1/20 0.49
MAOB P27338 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA2B P29275 1/20 0.47
NUDT1 P36639 1/20 0.46
GAA P10253 4/20 0.45
MGAM O43451 2/20 0.45
SI P14410 2/20 0.45
MGAM2 Q2M2H8 2/20 0.45
EGLN1 Q9GZT9 1/20 0.43
PARP1 P09874 2/20 0.41
NOS1 P29475 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GPR55 Q9Y2T6 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1170768 0.83 ADORA1 (0.61) PSMB8NPC1RAB9AADORA1ADORA3
SCHEMBL8956421 0.79 NPC1 (0.50) PSMB8NPC1RAB9AADORA1ADORA3
SCHEMBL3109602 0.79 MGAM (0.60) NPC1RAB9AGAAMGAMSI
SCHEMBL3973619 0.79 NPC1 (0.50) PSMB8NPC1RAB9AADORA1ADORA3
SCHEMBL215756 0.79 NUDT1 (0.70) PSMB8ADORA1ADORA3MAOBADORA2A
SCHEMBL9305483 0.79 RAB9A (0.50) PSMB8NPC1RAB9AGAAMGAM
SCHEMBL11739880 0.79 PSMB8 (0.56) PSMB8NPC1RAB9AADORA1ADORA3
SCHEMBL6843925 0.79 NPC1 (0.50) PSMB8NPC1RAB9ANUDT1GAA
SCHEMBL6118216 0.79 GAA (0.54) PSMB8NPC1RAB9ANUDT1GAA
SCHEMBL31534795 0.79 PSMB8 (0.56) PSMB8NPC1RAB9AADORA1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 366 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118126467-A Heat-resistant modified polyvinyl chloride power tube and preparation method thereof 杭州鼎新建科实业有限公司 2024-06-04 CN claimed
CN-111335033-A Neckerchief fabric for infant care and preparation method thereof 张海军 2020-06-26 CN claimed
US-8188254-B2 C-class oligonucleotide analogs with enhanced immunostimulatory potency COLEY PHARMACEUTICAL GMBH (DE) 2012-05-29 US claimed
EP-1978997-A1 TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS Apollo Life Sciences Limited (AU) 2008-10-15 EP claimed
WO-2007070983-A1 TRANSDERMAL DELIVERY OF PHARMACEUTICAL AGENTS APOLLO LIFE SCIENCES LIMITED (AU) 2007-06-28 WO claimed
EP-1730281-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS FOR INDUCING IL-10 RESPONSES Coley Pharmaceutical Group, Inc. (US) 2006-12-13 EP claimed
EP-1728863-A2 C-class oligonucleotide analogs with enhanced immunostimulatory potency Coley Pharmaceutical GmbH (DE) 2006-12-06 EP claimed
EP-1678303-A2 C-CLASS OLIGONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY POTENCY Coley Pharmaceutical GmbH (DE) 2006-07-12 EP claimed
WO-2005111057-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS FOR INDUCING IL-10 RESPONSES COLEY PHARMACEUTICAL GROUP, INC. (US) 2005-11-24 WO claimed
US-20050239734-A1 C-class oligonucleotide analogs with enhanced immunostimulatory potency COLEY PHARMACEUTICAL GMBH (DE) 2005-10-27 US claimed
EP-1578954-A2 5' CPG NUCLEIC ACIDS AND METHODS OF USE Coley Pharmaceutical Group, Inc. (US) 2005-09-28 EP claimed
WO-2005042018-A2 C-CLASS OLIGONUCLEOTIDE ANALOGS WITH ENHANCED IMMUNOSTIMULATORY POTENCY COLEY PHARMACEUTICAL GMBH (DE) 2005-05-12 WO claimed
US-20040171571-A1 5' CpG nucleic acids and methods of use COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-09-02 US claimed
WO-2004053104-A2 5’ CPG NUCLEIC ACIDS AND METHODS OF USE COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-06-24 WO claimed
US-12637646-B2 DNA origami cell sensing platform OHIO STATE INNOVATION FOUNDATION (US) 2026-05-26 US disclosed
US-20260139247-A1 ENGINEERED ENVELOPED VECTORS AND METHODS OF USE THEREOF GIGAMUNE INC (US) 2026-05-21 US disclosed
US-12631621-B2 Ligand discovery and gene delivery via retroviral surface display MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-05-19 US disclosed
WO-2004016805-A2 IMMUNOSTIMULATORY NUCLEIC ACIDS COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-02-26 WO disclosed
WO-2004005476-A2 NUCLEIC ACID COMPOSITIONS FOR STIMULATING IMMUNE RESPONSES COLEY PHARMACEUTICAL GROUP, INC. (US) 2004-01-15 WO disclosed
US-4594420-A Substituted with bromine or chlorine HOECHST AKTIENGESELLSCHAFT (DE) 1986-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260139247-A1 ENGINEERED ENVELOPED VECTORS AND METHODS OF USE THEREOF TMIGD3, TMPRSS11D, TMED2 PSMB8 1707/4885NPC1 197/4885RAB9A 3159/4885
US-12637646-B2 DNA origami cell sensing platform DNMT3A, EPCAM, CASR PSMB8 4724/4885NPC1 2283/4885RAB9A 4492/4885
US-12631621-B2 Ligand discovery and gene delivery via retroviral surface display TMIGD3, LDLR, VSIG8 PSMB8 3809/4885NPC1 745/4885RAB9A 904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.