Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 12/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.60 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.59 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12612196 | 0.81 | ADORA2A (0.57) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL6628380 | 0.78 | ADORA2A (0.65) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL24210278 | 0.77 | ADORA2A (0.76) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL6624543 | 0.77 | ADORA2A (0.64) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL17066859 | 0.76 | ADORA3 (0.60) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL14810415 | 0.75 | ADORA2A (1.00) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL14810416 | 0.75 | ADORA2A (0.67) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| Hydrochloric Acid SCHEMBL6627840 | 0.75 | ADORA2A (0.56) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL6624442 | 0.75 | CSNK1A1 (0.55) | ADORA3ADORA2AADORA1ADORA2BCSNK1A1 | |
| SCHEMBL6624206 | 0.75 | ADORA2A (0.60) | ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976753-B1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-6222035-B1 | AS ADENOSINE A.SUB.2A RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THERAPY OR OR PROPHYLAXIS OF VARIOUS DISEASES INDUCED BY HYPERACTIVITY OF ADENOSINE A.SUB.2A RECEPTORS SUCH AS PARKINSON'S DISEASE, SENILE DEMENTIA OR DEPRESSION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-0976753-A1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |