Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628380 | 0.90 | ADORA2A (0.65) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B | |
| SCHEMBL6624648 | 0.76 | ADORA2A (0.61) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL6627407 | 0.76 | ADORA2A (0.64) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B | |
| SCHEMBL6629612 | 0.75 | ADORA3 (0.60) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B | |
| SCHEMBL9327327 | 0.73 | ADORA3 (0.81) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7708567 | 0.73 | ADORA2A (0.51) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B | |
| SCHEMBL22013573 | 0.71 | CSNK1A1 (1.00) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B | |
| SCHEMBL9327042 | 0.71 | ADORA2A (0.81) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7829659 | 0.69 | ADORA3 (1.00) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL22013580 | 0.69 | ADORA2A (0.70) | CSNK1A1CSNK1DCSNK1EADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0976753-B1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2004-01-02 | — | — | EP | disclosed |
| US-6222035-B1 | AS ADENOSINE A.SUB.2A RECEPTOR ANTAGONISTS AND ARE USEFUL FOR THERAPY OR OR PROPHYLAXIS OF VARIOUS DISEASES INDUCED BY HYPERACTIVITY OF ADENOSINE A.SUB.2A RECEPTORS SUCH AS PARKINSON'S DISEASE, SENILE DEMENTIA OR DEPRESSION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-0976753-A1 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-02 | — | — | EP | disclosed |