SCHEMBL6629916

SCHEMBL6629916

O=C(O)C(O)CC(F)(F)Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.43
CES1 P23141 1/20 0.43
CPA1 P15085 2/20 0.42
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP1A2 P05177 2/20 0.41
LMNA P02545 1/20 0.40
CYP2D6 P10635 1/20 0.40
ALPI P09923 1/20 0.39
PKM P14618 1/20 0.39
PTGS1 P23219 1/20 0.39
XIAP P98170 1/20 0.39
SLC7A5 Q01650 1/20 0.39
KIF11 P52732 2/20 0.39
SLC6A2 P23975 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6633524 1.00 TRPA1 (0.43) TRPA1SMN1; SMN2HIF1ACES1CPA1
SCHEMBL4398300 0.81 ALPI (0.55) SMN1; SMN2HIF1AALPIPKMPTGS1
SCHEMBL4398295 0.81 ALPI (0.55) SMN1; SMN2HIF1AALPIPKMPTGS1
Hydrochloric Acid SCHEMBL2344664 0.79 ALPI (0.53) SMN1; SMN2HIF1AALPIPKMPTGS1
Hydrochloric Acid SCHEMBL2344672 0.79 ALPI (0.53) SMN1; SMN2HIF1AALPIPKMPTGS1
Bromide SCHEMBL2192294 0.79 ALPI (0.53) SMN1; SMN2HIF1AALPIPKMPTGS1
SCHEMBL346994 0.77 LMNA (0.43) CPA1CYP2C9CYP2C19ALDH1A1CYP3A4
Bromide SCHEMBL1200370 0.76 LMNA (0.42) CPA1CYP2C9CYP2C19ALDH1A1CYP3A4
SCHEMBL4406736 0.74 CTSB (0.38) TRPA1SMN1; SMN2HIF1ACES1CPA1
SCHEMBL4073030 0.74 CTSB (0.38) TRPA1SMN1; SMN2HIF1ACES1CPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed