Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629990 | 0.78 | NPSR1 (0.39) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL7102356 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8692679 | 0.68 | HIF1A (0.39) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8690517 | 0.68 | HIF1A (0.39) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8689317 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8690519 | 0.68 | HIF1A (0.39) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8689922 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL8692709 | 0.68 | ALDH1A1 (0.55) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL6631881 | 0.68 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHSD17B10HIF1A | |
| SCHEMBL6628665 | 0.62 | CA9 (0.51) | ALDH1A1HPGDKDM4EHSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379529-A2 | PYRANOCOUMARIN COMPOUNDS AS A NOVEL PHARMACOPHORE WITH ANTI-TB ACTIVITY | Sarawak Medichem Pharmaceuticals, Inc. (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002074777-A2 | PYRANOCOUMARIN COMPOUNDS AS A NOVEL PHARMACOPHORE WITH ANTI-TB ACTIVITY | SARAWAK MEDICHEM PHARMACEUTICALS, INC. (US) | 2002-09-26 | — | — | WO | disclosed |