Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632623 | 0.93 | GYS1 (0.36) | ATRALDH1A1SMN1; SMN2KCNK9MEN1 | |
| SCHEMBL6631222 | 0.93 | ATR (0.37) | ATRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6629085 | 0.91 | ALDH1A1 (0.34) | ATRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL6629112 | 0.91 | ALDH1A1 (0.34) | ATRALDH1A1SMN1; SMN2KCNK9MEN1 | |
| SCHEMBL6628507 | 0.89 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2KCNK9MEN1KMT2A | |
| SCHEMBL3845190 | 0.88 | RAB9A (0.43) | ATRALDH1A1SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL6629930 | 0.87 | CASR (0.35) | ALDH1A1KCNK9MEN1KMT2ANPC1 | |
| SCHEMBL6629666 | 0.85 | ABL1 (0.46) | MEN1KMT2A | |
| SCHEMBL6632050 | 0.85 | MCHR1 (0.41) | ATRNAMPTMEN1KMT2ARAB9A | |
| SCHEMBL6633056 | 0.84 | ABL1 (0.43) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379501-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | Boehringer Ingelheim Pharma GmbH & Co.KG (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002081445-A1 | INDOLINONES, SUBSTITUTED IN POSITION 6, AND THEIR USE AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |