SCHEMBL6630282

SCHEMBL6630282

CC(C)c1cc(Cc2ccc(C=O)cc2)c2ccccc2n1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADAM17 P78536 2/20 0.46
RAB9A P51151 2/20 0.40
MAPT P10636 3/20 0.38
ALDH1A1 P00352 2/20 0.38
TYR P14679 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.36
MAPK1 P28482 1/20 0.36
PTGS2 P35354 1/20 0.36
DHODH Q02127 1/20 0.36
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
ELANE P08246 1/20 0.35
KDM4E B2RXH2 1/20 0.35
POLB P06746 1/20 0.35
ERN1 O75460 1/20 0.35
CYP2A6 P11509 1/20 0.35
METAP1 P53582 1/20 0.35
CYP1A2 P05177 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3964970 0.83 CYP1A2 (0.51) ADAM17RAB9AALDH1A1KDM4ECYP1A2
SCHEMBL6630276 0.82 ADAM17 (0.45) ADAM17RAB9AMAPTALDH1A1L3MBTL1
SCHEMBL6487084 0.81 ADAM17 (0.46) ADAM17RAB9AMAPTALDH1A1L3MBTL1
SCHEMBL21027636 0.79 TNKS2 (0.44) ADAM17MAPTALDH1A1DHODHKMT2A
SCHEMBL3966407 0.77 ELANE (0.40) ADAM17ALDH1A1DHODHKMT2AMEN1
SCHEMBL3966410 0.76 ADAM17 (0.40) ADAM17RAB9AMAPTALDH1A1L3MBTL1
SCHEMBL2600753 0.72 CYP1A2 (0.60) RAB9AMAPTALDH1A1L3MBTL1KMT2A
SCHEMBL3970382 0.71 CYP1A2 (0.51) ADAM17RAB9AMAPTALDH1A1L3MBTL1
SCHEMBL8780460 0.70 CYP11B1 (0.40) ADAM17ALDH1A1MAPK1KMT2AMEN1
SCHEMBL24659879 0.69 ALDH1A1 (0.41) RAB9AMAPTALDH1A1L3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6720329-B2 ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB PHARMA 2004-04-13 US disclosed
EP-1373199-A4 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) BRISTOL MYERS SQUIBB PHARMA CO (US) 2004-04-07 EP disclosed
EP-1373199-A2 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) Bristol-Myers Squibb Pharma Company (US) 2004-01-02 EP disclosed
WO-2002074738-A2 SPIRO-CYCLIC BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF-ALPHA CONVERTING ENZYME (TAGE) BRISTOL-MYERS SQUIBB COMPANY (US) 2002-09-26 WO disclosed