Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630276 | 0.77 | ADAM17 (0.45) | SMN1; SMN2MAPK1RXFP1ADAM17MEN1 | |
| SCHEMBL8780501 | 0.76 | MEN1 (0.42) | CYP11B1CYP11B2NTRK1SMN1; SMN2ABCG2 | |
| SCHEMBL25523507 | 0.74 | CYP1A2 (0.53) | SMN1; SMN2RXFP1POLBKMT2AALDH1A1 | |
| SCHEMBL8780490 | 0.73 | KDR (0.36) | NTRK1SMN1; SMN2ABCG2CYP2A6USP2 | |
| SCHEMBL6630282 | 0.70 | ADAM17 (0.46) | MAPK1ADAM17CYP2A6POLBMEN1 | |
| SCHEMBL7849358 | 0.70 | TLR8 (0.42) | POLBMEN1KMT2AALDH1A1ATM | |
| SCHEMBL21027636 | 0.68 | TNKS2 (0.44) | SMN1; SMN2RXFP1ADAM17MEN1KMT2A | |
| SCHEMBL7984282 | 0.67 | MAPK1 (0.53) | NTRK1MAPK1ABCG2USP2MEN1 | |
| SCHEMBL6487073 | 0.67 | ADAM17 (0.45) | SMN1; SMN2RXFP1ADAM17POLBMEN1 | |
| SCHEMBL7979804 | 0.66 | L3MBTL1 (0.56) | MAPK1RXFP1ABCG2ABCB1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498722-B1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1997-07-30 | — | — | EP | disclosed |
| EP-0498722-A1 | Bicyclic nitrogen compounds, their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |