Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34752 | 1.00 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| SCHEMBL24533163 | 1.00 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| SCHEMBL10086753 | 1.00 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| SCHEMBL34592 | 1.00 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| Guanidine SCHEMBL663602 | 0.92 | SIGMAR1 (0.53) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| SCHEMBL139932 | 0.86 | CYP3A4 (0.57) | SIGMAR1HTTCYP3A4CYP2D6TSHR | |
| SCHEMBL23015567 | 0.86 | SIGMAR1 (0.46) | SIGMAR1HTTPOLBCYP3A4CYP2D6 | |
| SCHEMBL22402644 | 0.86 | CYP3A4 (0.57) | SIGMAR1HTTCYP3A4CYP2D6TSHR | |
| SCHEMBL155224 | 0.86 | CYP3A4 (0.57) | SIGMAR1HTTCYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL11843455 | 0.85 | CYP3A4 (0.59) | SIGMAR1HTTCYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846851-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2014-09-30 | — | — | US | claimed |
| US-8507640-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-08-13 | — | — | US | claimed |
| US-20130158226-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-06-20 | — | — | US | claimed |
| US-20120046437-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-02-23 | — | — | US | claimed |
| US-8846851-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2014-09-30 | — | — | US | disclosed |
| US-8507640-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-08-13 | — | — | US | disclosed |
| US-20130158226-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-06-20 | — | — | US | disclosed |
| US-20120046437-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046437-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | OGFOD1, PCNA, ODC1 | SIGMAR1 843/4885HTT 1918/4885POLB 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.