Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24533163 | 0.92 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL10086753 | 0.92 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL663131 | 0.92 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL34592 | 0.92 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL34752 | 0.92 | SIGMAR1 (0.55) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL14703713 | 0.81 | SIGMAR1 (0.40) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL14703708 | 0.81 | SIGMAR1 (0.40) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL14703680 | 0.81 | SIGMAR1 (0.40) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL14703507 | 0.81 | SIGMAR1 (0.40) | SIGMAR1HTTPOLBTSHRCYP3A4 | |
| SCHEMBL14703512 | 0.81 | SIGMAR1 (0.40) | SIGMAR1HTTPOLBTSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846851-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2014-09-30 | — | — | US | disclosed |
| US-8507640-B2 | Methods of ring opening polymerization and catalysts therefor | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-08-13 | — | — | US | disclosed |
| US-20130158226-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-06-20 | — | — | US | disclosed |
| US-20120046437-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046437-A1 | METHODS OF RING OPENING POLYMERIZATION AND CATALYSTS THEREFOR | OGFOD1, PCNA, ODC1 | SIGMAR1 843/4885HTT 1918/4885POLB 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.