Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095357 | 0.75 | HTR2A (0.46) | KMT2AKDM4EALDH1A1SMN1; SMN2MTNR1B | |
| SCHEMBL1903428 | 0.71 | DRD2 (0.41) | — | |
| SCHEMBL25722288 | 0.70 | SMN1; SMN2 (0.58) | KMT2AKDM4EALDH1A1SMN1; SMN2MTNR1B | |
| SCHEMBL6631121 | 0.70 | ESR1 (0.41) | ALDH1A1MTNR1B | |
| SCHEMBL2061237 | 0.66 | MTNR1B (0.45) | KMT2AKDM4EALDH1A1SMN1; SMN2MTNR1B | |
| SCHEMBL28812267 | 0.65 | MAOB (0.77) | SMN1; SMN2 | |
| SCHEMBL28812341 | 0.65 | MAOB (0.77) | SMN1; SMN2 | |
| SCHEMBL29843351 | 0.65 | MAOB (0.77) | SMN1; SMN2 | |
| SCHEMBL1096983 | 0.65 | HTR2C (0.46) | KMT2AKDM4EALDH1A1SMN1; SMN2MTNR1B | |
| SCHEMBL1094266 | 0.65 | HTR2A (0.48) | KMT2AKDM4EALDH1A1SMN1; SMN2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411881-A4 | 5HT sb 2C /sb RECEPTOR MODULATORS | ARENA PHARM INC (US) | 2004-07-07 | — | — | EP | disclosed |
| EP-1411881-A2 | 5HT sb 2C /sb RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003086306-A2 | 5HT2C RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. (US) | 2003-10-23 | — | — | WO | disclosed |