SCHEMBL6631491

SCHEMBL6631491

CCCCN(C(=O)[C@@H](CNC(=O)OC(C)(C)C)S(=O)(=O)Cc1ccccc1)C(O)c1nc2ccccc2s1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIPC P11150 3/20 0.41
LIPG Q9Y5X9 3/20 0.41
MAPK1 P28482 1/20 0.37
SYK P43405 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA7 P43166 1/20 0.36
CA14 Q9ULX7 1/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
ALDH1A1 P00352 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
CYP1A2 P05177 1/20 0.35
NFKB1 P19838 1/20 0.35
CYP2C19 P33261 1/20 0.35
STAT1 P42224 1/20 0.35
NFKB2 Q00653 1/20 0.35
RELA Q04206 1/20 0.35
PTPRB P23467 2/20 0.35
HDAC3 O15379 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6631485 0.85 HDAC3 (0.41) LIPCLIPGMAPK1PTPRBHDAC3
SCHEMBL6628452 0.83 PTPN1 (0.40) SYKALDH1A1SMN1; SMN2CTSK
SCHEMBL6632355 0.83 PTPN1 (0.40) SYKALDH1A1SMN1; SMN2CTSK
SCHEMBL6631414 0.80 LIPC (0.43) LIPCLIPGMAPK1SYKCA12
SCHEMBL6627818 0.78 SYK (0.36) SYKCA12CA1CA7CA14
SCHEMBL8373326 0.73 HDAC3 (0.45) MAPK1SYKNPC1RAB9AALDH1A1
SCHEMBL6630261 0.72 ACACB (0.38)
SCHEMBL6063420 0.69 ACACB (0.38) CYP1A2
SCHEMBL6631410 0.69 HDAC3 (0.43) LIPCLIPGMAPK1RAB9APTPRB
SCHEMBL6631409 0.69 HDAC3 (0.43) LIPCLIPGMAPK1RAB9APTPRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP claimed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO claimed
EP-1397340-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2004-03-17 EP disclosed
WO-2002098850-A2 CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS AXYS PHARMACEUTICALS, INC. (US) 2002-12-12 WO disclosed