Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 9/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6628452 | 1.00 | PTPN1 (0.40) | PTPN1PTPN2MAPTATMMEN1 | |
| SCHEMBL6630261 | 0.88 | ACACB (0.38) | PTPN1PTPN2 | |
| SCHEMBL6063420 | 0.85 | ACACB (0.38) | PTPN1PTPN2MAPTLMNA | |
| SCHEMBL6628447 | 0.84 | MAPT (0.42) | PTPN1PTPN2MAPTATMMEN1 | |
| SCHEMBL6061710 | 0.84 | MAPT (0.42) | PTPN1PTPN2MAPTATMMEN1 | |
| SCHEMBL6631491 | 0.83 | LIPC (0.41) | ALDH1A1SMN1; SMN2SYKCTSK | |
| SCHEMBL6062437 | 0.81 | PTPN2 (0.42) | PTPN1PTPN2MAPTATMALDH1A1 | |
| SCHEMBL6628528 | 0.81 | CTSK (0.37) | PTPN1PTPN2MAPTALDH1A1LMNA | |
| SCHEMBL6630253 | 0.75 | ACACB (0.36) | PTPN1PTPN2PPARGPPARAPPARD | |
| SCHEMBL6628517 | 0.75 | CTSK (0.46) | PTPN1PTPN2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397340-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-03-17 | — | — | EP | claimed |
| WO-2002098850-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS CATHEPSIN S INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |