Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TYMP | P19971 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649170 | 0.98 | KDM4E (0.71) | KDM4EALDH1A1LMNANPC1TYMP | |
| SCHEMBL4978570 | 0.89 | KDM4E (0.68) | KDM4EALDH1A1LMNANPC1TYMP | |
| SCHEMBL9872008 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1LMNANPC1MAPT | |
| SCHEMBL11736480 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1TYMPMAPTNPSR1 | |
| SCHEMBL17271402 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1TYMPMAPTPKM | |
| SCHEMBL648709 | 0.79 | TYMP (0.67) | KDM4EALDH1A1TYMPMAPTPKM | |
| SCHEMBL14502537 | 0.77 | ALDH1A1 (0.49) | KDM4EALDH1A1TYMPPKMFFAR3 | |
| SCHEMBL17271400 | 0.74 | L3MBTL1 (0.56) | KDM4EALDH1A1TYMPMAPTNPSR1 | |
| SCHEMBL11449106 | 0.73 | ALDH1A1 (0.65) | KDM4EALDH1A1LMNANPC1NPSR1 | |
| SCHEMBL7134419 | 0.70 | KDM4E (0.54) | KDM4EALDH1A1LMNANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490343-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | Neurogen Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082829-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |