Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29123449 | 0.81 | MAPT (0.50) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3077375 | 0.76 | SIRT1 (0.77) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6647601 | 0.76 | SIRT1 (0.53) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6630356 | 0.74 | SIRT1 (0.50) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6633089 | 0.71 | SIRT1 (0.48) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7706549 | 0.71 | SIRT1 (0.48) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7695938 | 0.71 | SIRT1 (0.74) | SIRT1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6632529 | 0.71 | SIRT1 (0.47) | SIRT1KDM4EPARP1MAPTCDC7 | |
| SCHEMBL10767952 | 0.70 | GRM5 (0.52) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL6630237 | 0.70 | SIRT1 (0.53) | SIRT1ALDH1A1HPGDHSD17B10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |