Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077375 | 0.76 | SIRT1 (0.77) | SIRT1PARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL6632649 | 0.76 | SIRT1 (0.53) | SIRT1PARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL6633917 | 0.73 | SIRT1 (0.53) | SIRT1PARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL29964792 | 0.72 | HAO1 (0.40) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL6630356 | 0.71 | SIRT1 (0.50) | SIRT1PARP1MAPTKDM4EALDH1A1 | |
| SCHEMBL6632529 | 0.71 | SIRT1 (0.47) | SIRT1PARP1MAPTKDM4EGLA | |
| SCHEMBL30655822 | 0.70 | NOTUM (0.53) | PARP1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL27874781 | 0.70 | NOTUM (0.53) | PARP1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6650786 | 0.70 | SIRT1 (0.53) | SIRT1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1030659 | 0.70 | SIRT1 (1.00) | SIRT1MAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480977-A2 | SUBSTITUTED ARYL COMPOUNDS FOR TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003070728-A2 | AZABICYCLO-SUBSTITUTED BENZOYLAMIDES AND THIOAMIDES FOR TREATMENT OF CNS-RELATED DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |