Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512172 | 0.93 | HTR6 (0.62) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL2510832 | 0.87 | HTR6 (0.68) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL29617199 | 0.87 | HTR6 (0.68) | HTR6MEN1HTTKMT2AALDH1A1 | |
| Hydroxyamine SCHEMBL14672692 | 0.85 | HTR6 (0.65) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL20742991 | 0.82 | HTR6 (0.62) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL13323640 | 0.81 | HDAC3 (0.55) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL6236469 | 0.80 | MET (0.52) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL29425682 | 0.78 | HDAC1 (0.52) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL28692303 | 0.78 | HDAC1 (0.52) | HTR6MEN1HTTKMT2AALDH1A1 | |
| SCHEMBL1395018 | 0.78 | HTR6 (0.69) | HTR6MEN1HTTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444210-A1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040108-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |