Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 5/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257136 | 0.84 | OPRM1 (0.37) | KCNH2PTPN11PARP1GRM2HTR3A | |
| SCHEMBL7257145 | 0.82 | KCNH2 (0.37) | KCNH2PARP1CHRM1GRM2HTR3A | |
| SCHEMBL7257413 | 0.82 | PARP1 (0.36) | KCNH2PARP1GRM2HTR3ACRHR1 | |
| SCHEMBL6508880 | 0.81 | CCR4 (0.39) | HRH1CYP2D6PARP1PDCD1CD274 | |
| SCHEMBL6630822 | 0.80 | PARP1 (0.34) | HRH1KCNH2CYP2D6PARP1CHRM1 | |
| SCHEMBL7257414 | 0.80 | KCNH2 (0.39) | KCNH2PARP1GRM2HTR3A | |
| SCHEMBL6505984 | 0.80 | PARP1 (0.36) | CYP2D6PARP1CRHR1 | |
| Hydrochloric Acid SCHEMBL6508148 | 0.79 | PARP1 (0.36) | KCNH2PARP1GRM2HTR3A | |
| SCHEMBL6630805 | 0.79 | PARP1 (0.43) | PARP1HTR6HTR3A | |
| SCHEMBL6631361 | 0.79 | HDAC6 (0.46) | KCNH2PARP1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309594-B1 | BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2004-12-15 | — | — | EP | claimed |