SCHEMBL6631361

SCHEMBL6631361

O=C1CCn2c(N3CCC(Cc4ccccc4)CC3)nc3cccc1c32

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.46
ALDH1A1 P00352 8/20 0.46
MAPT P10636 5/20 0.46
HTT P42858 4/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
LMNA P02545 4/20 0.46
NPSR1 Q6W5P4 3/20 0.46
POLB P06746 1/20 0.46
TSHR P16473 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPK1 P28482 4/20 0.43
ALOX15 P16050 2/20 0.42
SIGMAR1 Q99720 3/20 0.42
TP53 P04637 1/20 0.41
XBP1 P17861 1/20 0.41
HTR1A P08908 1/20 0.41
NTSR1 P30989 1/20 0.41
GPR84 Q9NQS5 1/20 0.41
KDM4E B2RXH2 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6510289 0.99 HDAC6 (0.46) HDAC6ALDH1A1MAPTHTTMEN1
SCHEMBL7257145 0.83 KCNH2 (0.37) HDAC6ALDH1A1MAPTMEN1KMT2A
SCHEMBL7257414 0.83 KCNH2 (0.39) KCNH2GRM2PARP1
SCHEMBL7257136 0.82 OPRM1 (0.37) KCNH2GRM2PARP1
SCHEMBL7262771 0.79 AVPR1A (0.43) SIGMAR1PARP1
SCHEMBL6508880 0.79 CCR4 (0.39) PARP1
SCHEMBL6633308 0.79 HRH1 (0.43) KCNH2GRM2PARP1
SCHEMBL7258019 0.77 GHSR (0.39) PARP1
SCHEMBL7257413 0.77 PARP1 (0.36) KCNH2GRM2PARP1
SCHEMBL6630805 0.77 PARP1 (0.43) ALDH1A1HTTMAPK1HTR1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1309594-B1 BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2004-12-15 EP claimed
EP-1309594-B1 BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI AVENTIS (FR) 2004-12-15 EP disclosed
EP-1309594-A1 BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2003-05-14 EP disclosed
WO-2002012239-A1 BENZIMIDAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-SYNTHELABO (FR) 2002-02-14 WO disclosed