SCHEMBL6633348

SCHEMBL6633348

CCOC(=O)Cn1c(COc2ccc(C#N)cc2)nc2ccc(N)cc21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.48
ALOX5AP P20292 3/20 0.47
MAPT P10636 5/20 0.46
NPC1 O15118 3/20 0.46
NLRP3 Q96P20 1/20 0.46
NPSR1 Q6W5P4 1/20 0.42
HSD17B10 Q99714 3/20 0.42
HTT P42858 2/20 0.42
RAB9A P51151 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C19 P33261 1/20 0.40
MAPK1 P28482 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6636062 0.92 MAPT (0.52) PPARGALOX5APMAPTNPC1NLRP3
SCHEMBL6639694 0.86 IRAK4 (0.45) PPARGALOX5APMAPTNPC1NLRP3
SCHEMBL6634205 0.80 KMT2A (0.51) MAPTNPC1NLRP3NPSR1HSD17B10
SCHEMBL6635525 0.80 AR (0.48) ALOX5APMAPTNPSR1HSD17B10HTT
SCHEMBL6633352 0.80 LMNA (0.40) MAPTNPSR1HSD17B10HTTMEN1
SCHEMBL6633284 0.80 ALOX5AP (0.39) PPARGALOX5APMAPTNPC1NLRP3
SCHEMBL6633282 0.78 CACNA1H (0.39) PPARGALOX5APMAPTNPC1NLRP3
SCHEMBL6634421 0.77 HCRTR2 (0.39) PPARGALOX5APMAPTNPC1NLRP3
SCHEMBL6635871 0.75 BRPF1 (0.48) MAPTNPC1NLRP3NPSR1HSD17B10
SCHEMBL6634416 0.75 MAPT (0.36) PPARGALOX5APMAPTNPC1NLRP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100795-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2004-06-09 EP disclosed
EP-1100795-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) 2001-05-23 EP disclosed
US-6121308-A INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE BOEHRINGER INGELHEIM KG (DE) 2000-09-19 US disclosed
WO-2000008014-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-02-17 WO disclosed