Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6635871 | 0.94 | BRPF1 (0.48) | ARBRPF1SMARCA2MEN1KMT2A | |
| SCHEMBL8145525 | 0.90 | F2 (0.52) | ARBRPF1SMARCA2MEN1KMT2A | |
| SCHEMBL6634416 | 0.85 | MAPT (0.36) | ARBRPF1MEN1KMT2AMAPT | |
| SCHEMBL8027014 | 0.84 | F2 (0.48) | BRPF1SMARCA2MEN1KMT2AMAPT | |
| SCHEMBL6635529 | 0.83 | BRPF1 (0.45) | BRPF1SMARCA2MEN1KMT2AALDH1A1 | |
| SCHEMBL8029744 | 0.83 | F2 (0.60) | BRPF1SMARCA2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8101752 | 0.83 | GLO1 (0.43) | ARBRPF1KMT2AALDH1A1LMNA | |
| SCHEMBL6633282 | 0.83 | CACNA1H (0.39) | ARMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6634421 | 0.80 | HCRTR2 (0.39) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL6633348 | 0.80 | PPARG (0.48) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |