Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SI | P14410 | 1/20 | 0.30 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL73619 | 1.00 | FFAR3 (0.47) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL6633787 | 1.00 | FFAR3 (0.47) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL6761218 | 1.00 | FFAR3 (0.47) | FFAR3LCKFYNALDH1A1LMNA | |
| Bicarbonate SCHEMBL28800487 | 0.90 | LMNA (0.41) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL30343482 | 0.89 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL14125983 | 0.89 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL28017923 | 0.89 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL896834 | 0.89 | — | — | |
| Acetic Acid SCHEMBL361746 | 0.89 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1LMNA | |
| Acetic Acid SCHEMBL6150066 | 0.86 | FFAR3 (0.54) | FFAR3LCKFYNALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326508-B1 | UNITARY BRUSH HAVING ABRASIVE COATED BRISTLES AND METHOD OF MAKING THE SAME | 3M INNOVATIVE PROPERTIES CO (US) | 2004-05-19 | — | — | EP | disclosed |