Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9549434 | 1.00 | IGF1R (0.47) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL2880972 | 0.87 | MAOB (0.39) | IGF1RALOX15ESR1ADRA2AADORA3 | |
| SCHEMBL10707889 | 0.83 | CYP1A2 (0.50) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL10571160 | 0.82 | IGF1R (0.61) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL9694171 | 0.82 | IGF1R (0.48) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL2458605 | 0.82 | IGF1R (0.48) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL10639385 | 0.82 | IGF1R (0.48) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL2875216 | 0.80 | PPARG (0.38) | IGF1RALOX15FDFT1ESR1ADRA2A | |
| SCHEMBL6546754 | 0.80 | IGF1R (0.64) | IGF1RALOX15CYP1A2CYP2A6TAAR1 | |
| SCHEMBL6682661 | 0.79 | SIGMAR1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036077-B1 | PHOTOCHROMIC PYRANO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6106744-A | HAVING A SUBSTITUTED OR UNSUBSTITUTED ?S? PYRAN RING, THE 3,4 POSITIONS OF WHICH ARE FUSED TO THE F SIDE OF THE NAPHTHO PORTION OF THE NAPHTHOPYRAN, AND CERTAIN SUBSTITUENTS AT THE 2-POSITION OF THE ?T? PYRAN RING. | PPG INDUSTRIES OHIO, INC. (US) | 2000-08-22 | — | — | US | disclosed |