Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 7/20 | 0.68 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1052113 | 0.98 | — | — | |
| Bromide SCHEMBL10851882 | 0.94 | TBXAS1 (0.72) | TBXAS1HMOX1NOS1 | |
| Bromide SCHEMBL28914614 | 0.92 | TBXAS1 (0.76) | TBXAS1HMOX1NOS1 | |
| Bromide SCHEMBL28915325 | 0.92 | TBXAS1 (0.76) | TBXAS1HMOX1NOS1 | |
| SCHEMBL2473495 | 0.91 | TBXAS1 (0.75) | TBXAS1HMOX1NOS1 | |
| SCHEMBL28281551 | 0.89 | TBXAS1 (0.79) | TBXAS1HMOX1NOS1 | |
| SCHEMBL21839255 | 0.89 | TBXAS1 (0.79) | TBXAS1HMOX1NOS1 | |
| SCHEMBL28280378 | 0.89 | TBXAS1 (0.79) | TBXAS1HMOX1NOS1 | |
| Bromide SCHEMBL3523586 | 0.86 | — | — | |
| Bromide SCHEMBL19149858 | 0.84 | TBXAS1 (0.95) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109336944-B | Tripterine imidazole derivative and preparation method and application thereof | 中国药科大学 | 2021-04-27 | — | — | CN | disclosed |
| CN-111351934-B | Marker immunosensor for diagnosing early lung cancer tumor and preparation method and application thereof | 青岛大学附属医院 | 2020-10-20 | — | — | CN | disclosed |
| CN-111351934-A | Marker immunosensor for diagnosing early lung cancer tumor and preparation method and application thereof | 魏雪 | 2020-06-30 | — | — | CN | disclosed |
| CN-110299527-B | Lithium ion battery cathode material and preparation method thereof | 张蓓 | 2020-03-31 | — | — | CN | disclosed |
| EP-2984091-B1 | DIHYDROPYRIDO PYRIMIDINE COMPOUNDS AS AUTOTAXIN INHIBITORS | LILLY CO ELI (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9550774-B2 | Dihydropyrido pyrimidine compounds as autotaxin inhibitors | ELI LILLY AND COMPANY (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150368240-A1 | DIHYDROPYRIDO PYRIMIDINE COMPOUNDS AS AUTOTAXIN INHIBITORS | ELI LILLY AND COMPANY (US) | 2015-12-24 | — | — | US | disclosed |
| EP-0842933-B1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-08-04 | — | — | EP | disclosed |
| US-5843957-A | Naphthyridine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1998-12-01 | — | — | US | disclosed |
| EP-0842933-A1 | NOVEL NAPHTHYRIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-05-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368240-A1 | DIHYDROPYRIDO PYRIMIDINE COMPOUNDS AS AUTOTAXIN INHIBITORS | ENPP2, NUDT1, DPYD | TBXAS1 86/4885HMOX1 3315/4885PRKCI 4185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.