Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607445 | 0.79 | SLC2A1 (0.54) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL13075989 | 0.70 | ALOX15 (0.77) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL297225 | 0.67 | ALOX15 (1.00) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL2073956 | 0.67 | ALOX15 (0.71) | ALOX15MAPTGAAALDH1A1P2RY12 | |
| SCHEMBL10202005 | 0.66 | ALOX15 (0.79) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL5717811 | 0.65 | P2RY12 (0.64) | ALOX15KMT2AMEN1P2RY12 | |
| SCHEMBL2072605 | 0.65 | ALOX15 (0.77) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL6387003 | 0.65 | ALOX15 (0.77) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL31389251 | 0.65 | ALOX15 (0.77) | ALOX15LMNAHPGDSMN1; SMN2MAPT | |
| SCHEMBL4409321 | 0.65 | ALOX15 (0.77) | ALOX15LMNAHPGDSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1359915-A4 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1359915-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | Smithkline Beecham (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002058702-A1 | UROTENSIN-II RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-08-01 | — | — | WO | disclosed |