Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21332520 | 0.81 | HSD17B10 (0.42) | CYP2C19CYP2C9HSD17B10ALOX15TSHR | |
| SCHEMBL442435 | 0.79 | FFAR1 (0.43) | CYP2C19CYP2C9HSD17B10ALOX15TSHR | |
| SCHEMBL13652110 | 0.78 | ALDH1A1 (0.43) | CYP2C19CYP2C9MAPTHTTNPSR1 | |
| SCHEMBL28712591 | 0.78 | CES2 (0.39) | CYP2C19CYP2C9MAPTRAB9AHTT | |
| SCHEMBL28093205 | 0.75 | MAPT (0.40) | CYP2C19CYP2C9HSD17B10TSHRMAPT | |
| SCHEMBL28786495 | 0.74 | CES2 (0.45) | TSHRRAB9ANPC1CES2CES1 | |
| SCHEMBL11850942 | 0.74 | CYP2C19 (0.41) | CYP2C19CYP2C9HSD17B10TSHRMAPT | |
| SCHEMBL11570417 | 0.74 | GRIN2D (0.49) | CYP2C19CYP2C9HSD17B10TSHRMAPT | |
| SCHEMBL28600329 | 0.72 | TSHR (0.53) | CYP2C19CYP2C9HSD17B10TSHRMAPT | |
| SCHEMBL9473461 | 0.71 | SRD5A2 (0.55) | CYP2C19CYP2C9HSD17B10ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472219-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003053978-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-07-03 | — | — | WO | disclosed |