SCHEMBL6635463

SCHEMBL6635463

Cc1c(CNc2ccc(C#N)cc2)oc2cc(N)ccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.41
MAOB P27338 7/20 0.40
SRC P12931 1/20 0.40
TDO2 P48775 2/20 0.36
CA12 O43570 2/20 0.36
CA9 Q16790 2/20 0.36
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CA1 P00915 1/20 0.36
GLA P06280 1/20 0.36
GAA P10253 1/20 0.36
HPGD P15428 1/20 0.36
CASP1 P29466 1/20 0.36
CASP7 P55210 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MAOA P21397 1/20 0.35
NOS3 P29474 1/20 0.35
NOS1 P29475 1/20 0.35
GHSR Q92847 1/20 0.35
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8032293 0.81 MAOB (0.47) IDO1MAOBSRCCA12CA9
SCHEMBL6635484 0.77 MAOB (0.43) MAOBCA12CA9CA1
SCHEMBL11877181 0.74 MAPT (0.44) IDO1MAOBSRCCA12CA9
SCHEMBL6641313 0.71 MEN1 (0.48) ALDH1A1GAA
SCHEMBL6273677 0.69 IDH1 (0.42) IDO1CA12KDM4EALDH1A1CA1
SCHEMBL7449274 0.69 HSD17B3 (0.44) IDO1MAOBKDM4EALDH1A1GLA
SCHEMBL8026433 0.68 MAOB (0.37) IDO1MAOBSRCTDO2CA12
SCHEMBL11935852 0.68 GHSR (0.53) IDO1CA12KDM4EALDH1A1CA1
SCHEMBL5713602 0.67 EGFR (0.51) MAOBCA12CA9ALDH1A1CA1
SCHEMBL2000840 0.64 SRC (0.63) MAOBSRCCA12CA9KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100795-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2004-06-09 EP disclosed
EP-1100795-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) 2001-05-23 EP disclosed
US-6121308-A INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE BOEHRINGER INGELHEIM KG (DE) 2000-09-19 US disclosed
WO-2000008014-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-02-17 WO disclosed