SCHEMBL6635501

SCHEMBL6635501

N#Cc1ccc(CSc2nc3ccc(N)cc3s2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 9/20 0.67
MEN1 O00255 5/20 0.67
KMT2A Q03164 5/20 0.67
ALDH1A1 P00352 5/20 0.67
CYP2C9 P11712 1/20 0.63
RAB9A P51151 3/20 0.60
NPC1 O15118 2/20 0.60
NFKB1 P19838 1/20 0.60
NFKB2 Q00653 1/20 0.60
RELA Q04206 1/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
L3MBTL1 Q9Y468 4/20 0.51
KEAP1 Q14145 1/20 0.51
APP P05067 1/20 0.51
LMNA P02545 2/20 0.49
CYP3A4 P08684 1/20 0.48
HPGD P15428 1/20 0.47
SHMT2 P34897 1/20 0.47
MAPK1 P28482 1/20 0.47
TDP1 Q9NUW8 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6636282 0.83 MAPT (0.68) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL8991265 0.83 MAPT (0.74) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL9353715 0.82 RAB9A (0.61) MAPTKMT2AALDH1A1CYP2C9RAB9A
SCHEMBL30370212 0.78 APP (0.54) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL29016610 0.78 APP (0.54) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL1060971 0.75 CYP1A2 (0.67) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL617400 0.74 KEAP1 (0.69) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL865987 0.71 KEAP1 (0.74) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL2031038 0.71 APP (0.52) MAPTMEN1KMT2AALDH1A1CYP2C9
SCHEMBL624557 0.70 KEAP1 (0.59) MAPTMEN1KMT2AALDH1A1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100795-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2004-06-09 EP disclosed
EP-1100795-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) 2001-05-23 EP disclosed
US-6121308-A INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE BOEHRINGER INGELHEIM KG (DE) 2000-09-19 US disclosed
WO-2000008014-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-02-17 WO disclosed