SCHEMBL6636352

SCHEMBL6636352

CCOC(=O)CN(c1ccc2c(C)c(CNc3ccc(C(=N)N)cc3)oc2c1)S(=O)(=O)c1cccc2c1NCCC2

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
F2 P00734 5/20 0.39
NQO2 P16083 1/20 0.32
F10 P00742 1/20 0.32
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
GLA P06280 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
CASP1 P29466 1/20 0.31
HTT P42858 1/20 0.31
CASP7 P55210 1/20 0.31
ATM Q13315 1/20 0.31
HSD17B10 Q99714 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
IGLV6-57 P01721 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6635424 0.92 F2 (0.47) F2MAPT
SCHEMBL6635830 0.90 HCRTR2 (0.32) F2KDM4EALDH1A1LMNAGLA
SCHEMBL6636555 0.83 F2 (0.58) F2NQO2ALDH1A1LMNAMAPT
Hydrochloric Acid SCHEMBL6636009 0.83 F2 (0.57) F2NQO2ALDH1A1LMNAMAPT
SCHEMBL6632770 0.82 TSHR (0.40) F2NQO2KDM4EALDH1A1LMNA
SCHEMBL6636348 0.75 F2 (0.36) F2NQO2F10ALDH1A1LMNA
SCHEMBL6637534 0.75 F2 (0.68) F2ALDH1A1MAPT
SCHEMBL6635648 0.74 F2 (0.46) F2ALDH1A1MAPT
SCHEMBL6638686 0.73 F2 (0.44) F2ALDH1A1LMNAMAPT
SCHEMBL6635601 0.72 F2 (0.57) F2F10ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1100795-B1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA (DE) 2004-06-09 EP disclosed
EP-1100795-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM ZENTRALE GMBH (DE) 2001-05-23 EP disclosed
US-6121308-A INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE BOEHRINGER INGELHEIM KG (DE) 2000-09-19 US disclosed
WO-2000008014-A1 DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-02-17 WO disclosed