Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10546979 | 1.00 | MAPT (0.49) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL4535120 | 1.00 | MAPT (0.49) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL4837230 | 0.86 | KDM4E (0.51) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL10543594 | 0.85 | MAPT (0.49) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL4828429 | 0.81 | MAPT (0.45) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL28006247 | 0.81 | MAPT (0.55) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL23499947 | 0.80 | CNR2 (0.59) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL30676839 | 0.79 | NCEH1 (0.65) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL979842 | 0.79 | CA12 (0.58) | MAPTKDM4EHTTALDH1A1HPGD | |
| SCHEMBL3357585 | 0.79 | NCEH1 (0.65) | MAPTKDM4EHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474140-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | Pharmagene Laboratories Ltd (GB) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003068226-A1 | 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS | PHARMAGENE LABORATORIES LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |