Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577726 | 0.82 | ESR1 (0.48) | POLBENPP2CA2LMNASERPINE1 | |
| SCHEMBL17180008 | 0.80 | PKM (0.50) | POLBENPP2CA2LMNASERPINE1 | |
| SCHEMBL5496236 | 0.79 | POLB (0.62) | POLBCA2ALDH1A1 | |
| SCHEMBL137017 | 0.77 | CA2 (0.45) | POLBENPP2CA2LMNAHPGD | |
| SCHEMBL1759263 | 0.74 | AMY1A (0.53) | POLBAKR1C3HTTGABRA1GABRB2 | |
| SCHEMBL5501492 | 0.74 | POLB (0.56) | POLBCA2PTGS1 | |
| SCHEMBL4665771 | 0.74 | EGFR (0.46) | POLBCA2HTTGABRA1GABRB2 | |
| SCHEMBL1134252 | 0.73 | BRD4 (0.34) | ENPP2LMNAPTGS1PTGS2ALDH1A1 | |
| SCHEMBL5020928 | 0.73 | SERPINE1 (0.61) | ENPP2CA2AKR1C3LMNASERPINE1 | |
| SCHEMBL136274 | 0.73 | ERN1 (0.53) | ENPP2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487797-A1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003078397-A1 | HETERO-BRIDGE SUBSTITUTED 8-ARYLQUINOLINE PDE4 INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2003-09-25 | — | — | WO | disclosed |