Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.94 |
| ▸ | HTR1D | P28221 | 1/20 | 0.94 |
| ▸ | HTR1B | P28222 | 1/20 | 0.94 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.72 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.72 |
| ▸ | HTR3B | O95264 | 3/20 | 0.72 |
| ▸ | HTR3A | P46098 | 3/20 | 0.72 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.72 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.72 |
| ▸ | HTR5A | P47898 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.51 |
| ▸ | KHK | P50053 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777946 | 0.85 | HTR1A (0.70) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| SCHEMBL234280 | 0.84 | ADRB1 (1.00) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| SCHEMBL2410870 | 0.84 | ADRB1 (1.00) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| SCHEMBL7838014 | 0.83 | ADRB1 (1.00) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| SCHEMBL379449 | 0.83 | ADRB1 (1.00) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| Bromide SCHEMBL11070661 | 0.82 | ADRB1 (0.96) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| Hydrochloric Acid SCHEMBL2302729 | 0.82 | ADRB1 (0.96) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| Piperazine SCHEMBL8590918 | 0.82 | ADRB1 (0.96) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| Hydrochloric Acid SCHEMBL1724680 | 0.82 | ADRB1 (0.96) | HTR1AHTR1DHTR1BADRB1HTR3E | |
| Hydrochloric Acid SCHEMBL1706127 | 0.81 | ADRB1 (0.97) | HTR1AHTR1DHTR1BADRB1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-B1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2004-06-16 | — | — | EP | disclosed |
| US-6465482-B2 | ANTIDEPRESSANTS; ANXIOLYTIC AGENTS; SEROTONIN-AFFECTED NERVOUS SYSTEM DISORDERS; ACTING AT THE 5-HT1A AUTORECEPTORS CONCOMMITANTLY WITH 5-HT TRANSPORTERS; ANTISEROTONIN AGENTS; SEROTONIN REUPTAKE INHIBITORS; HT3 RECEPTOR ANTAGONISTS | WYETH | 2002-10-15 | — | — | US | disclosed |
| US-6313126-B1 | FOR THRERAPY OF DISORDERS ASSOCIATED WITH DYSFUNCTION IN SEROTONERGIC NEUROTRANSMISSION, INCLUDING DEPRESSION AND ANXIETY | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |