SCHEMBL6637835

SCHEMBL6637835

Cn1c(C(F)(F)F)cc(=O)n(-c2cc(Oc3cnccc3OCc3ccccc3)c(N)cc2F)c1=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.35
CYP11B1 P15538 2/20 0.35
CYP11B2 P19099 2/20 0.35
GPBAR1 Q8TDU6 3/20 0.33
BCAT1 P54687 2/20 0.33
PTGER1 P34995 2/20 0.33
LRRK2 Q5S007 1/20 0.32
ALDH1A1 P00352 2/20 0.32
MAPT P10636 1/20 0.32
HSD17B10 Q99714 1/20 0.32
KDM4C Q9H3R0 1/20 0.32
LMNA P02545 1/20 0.32
HIF1A Q16665 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
HPGD P15428 1/20 0.31
MET P08581 2/20 0.31
HGF P14210 1/20 0.31
MST1R Q04912 1/20 0.31
MAPK14 Q16539 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1527258 0.91 BCAT1 (0.38) BCAT1PTGER1ALDH1A1MAPTHSD17B10
SCHEMBL6639038 0.90 MEN1 (0.35) CYP19A1CYP11B1CYP11B2GPBAR1BCAT1
SCHEMBL6638566 0.88 CYP11B1 (0.35) CYP19A1CYP11B1CYP11B2GPBAR1BCAT1
SCHEMBL7228151 0.85 GAA (0.39) BCAT1PTGER1ALDH1A1MAPTLMNA
SCHEMBL7226295 0.83 TRIM24 (0.40) BCAT1ALDH1A1KDM4EGAAHPGD
SCHEMBL7852568 0.82 FFAR1 (0.33) CYP19A1CYP11B1CYP11B2BCAT1ALDH1A1
SCHEMBL1527259 0.81 BCAT1 (0.39) BCAT1PTGER1ALDH1A1LMNAMAPK14
SCHEMBL3246458 0.80 BCAT1 (0.38) BCAT1ALDH1A1MAPTLMNABCAT2
SCHEMBL6642464 0.79 MEN1 (0.35) CYP19A1CYP11B1CYP11B2GPBAR1BCAT1
SCHEMBL8926019 0.79 PPOX (0.40) BCAT1PTGER1ALDH1A1LMNAMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP disclosed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US disclosed
EP-1122244-A1 Uracil compounds and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-08 EP disclosed