Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | CLK2 | P49760 | 2/20 | 0.55 |
| ▸ | CLK3 | P49761 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | LTA4H | P09960 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 6/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636304 | 0.91 | CLK2 (0.65) | HRH3DRD2DRD3CLK2CLK3 | |
| SCHEMBL6534972 | 0.83 | HRH3 (0.86) | HRH3DRD2DRD3LTA4HACHE | |
| SCHEMBL18450584 | 0.80 | CLK2 (0.60) | HRH3DRD2DRD3CLK2CLK3 | |
| SCHEMBL18444329 | 0.79 | CLK2 (0.87) | CLK2CLK3DYRK1A | |
| SCHEMBL6301198 | 0.77 | HRH3 (1.00) | HRH3LTA4HACHEKDR | |
| SCHEMBL18440006 | 0.77 | CLK2 (0.70) | CLK2CLK3DYRK1A | |
| SCHEMBL18437212 | 0.77 | CLK2 (0.72) | DRD2DRD3CLK2CLK3DYRK1A | |
| SCHEMBL20421588 | 0.77 | CLK2 (0.74) | DRD2DRD3CLK2CLK3DYRK1A | |
| SCHEMBL14115608 | 0.73 | KDM4E (0.63) | ACHE | |
| SCHEMBL25059331 | 0.72 | LTA4H (0.87) | HRH3LTA4HPTGS2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997465-B1 | Azaindole derivatives and their use as antithrombotic agents | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6359136-B1 | AZAINDOLE COMPOUND | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| US-6265416-B1 | ANTICOAGULANTS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| EP-0997465-A1 | Azaindole derivatives and their use as antithrombotic agents | ELI LILLY AND COMPANY (US) | 2000-05-03 | — | — | EP | disclosed |