Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366627 | 0.86 | CA12 (0.49) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL12217295 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| SCHEMBL12193374 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| SCHEMBL5603445 | 0.79 | ALDH1A1 (0.55) | NPC1RAB9ALMNASLC6A2ALDH1A1 | |
| SCHEMBL6570361 | 0.78 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL11377704 | 0.76 | SMN1; SMN2 (0.66) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| SCHEMBL10711397 | 0.76 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| Trifluoroacetic Acid SCHEMBL27817954 | 0.75 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| SCHEMBL30753585 | 0.75 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2LMNAPGR | |
| SCHEMBL12320823 | 0.75 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2LMNAPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757685-B1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER (US) | 2004-07-21 | — | — | EP | disclosed |
| US-5854232-A | Acyclic anc cyclic amides as neurotransmitter release enhancers | PFIZER INC. (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0757685-A1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER INC. (US) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029909-A1 | NOVEL ACYCLIC AND CYCLIC AMIDES AS NEUROTRANSMITTER RELEASE ENHANCERS | PFIZER INC. (US) | 1995-11-09 | — | — | WO | disclosed |