Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320414 | 0.78 | CYP1A2 (0.50) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL6637951 | 0.78 | NPC1 (0.52) | RAB9ANPC1PTPRASMN1; SMN2ALDH1A1 | |
| SCHEMBL28018657 | 0.77 | CYP1A2 (0.49) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL6638562 | 0.76 | FDPS (0.54) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL9366627 | 0.76 | CA12 (0.49) | RAB9ANPC1PTPRASMN1; SMN2CYP1A2 | |
| SCHEMBL10759826 | 0.76 | CYP1A2 (0.49) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL13343107 | 0.76 | SMN1; SMN2 (0.50) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL2205706 | 0.75 | RAB9A (0.54) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL8558681 | 0.74 | POLB (0.46) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 | |
| SCHEMBL21298 | 0.74 | PTPRA (0.56) | RAB9ANPC1PTPRAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892790-B1 | NEW QUINAZOLINE-4-AMINO-2-(PIPERIDINE-1-YL-4-SUBSTITUTED) DERIVATIVES HAVING ANTI-HYPERTENSIVE ACTIVITY, A METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE | ROTTA RESEARCH LAB (IT) | 2004-04-14 | — | — | EP | disclosed |
| US-5985885-A | USEFUL IN THE TREATMENT OF HYPERTENSION, CONGESTIVE HEART FAILURE, PROSTATE HYPERTROPHY, VARIOUS URINARY TRACT DISORDERS AND PATHOLOGICAL SYMPTOMS CAUSED BY HYPERACTIVITY OR DISFUNCTIONING OF THE NORADRENERGIC NEURAL SYSTEM | ROTTA RESEARCH LABORATORIUM S.P.A. (IT) | 1999-11-16 | — | — | US | disclosed |