Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6638383 | 0.78 | KMT2A (0.50) | MEN1KMT2APOLB | |
| SCHEMBL6635658 | 0.77 | NOS3 (0.47) | FFAR1MEN1KMT2ACYP19A1MAOB | |
| SCHEMBL6638696 | 0.77 | KMT2A (0.40) | GRM5MEN1KMT2APGR | |
| SCHEMBL6635377 | 0.76 | PDCD1 (0.42) | GRM5FFAR1MEN1KMT2ACYP19A1 | |
| SCHEMBL6637931 | 0.73 | KMT2A (0.56) | MEN1KMT2APOLB | |
| SCHEMBL8109356 | 0.71 | GRM5 (0.43) | GRM5FFAR1MEN1KMT2APDCD1 | |
| SCHEMBL11520347 | 0.69 | PGR (0.63) | MEN1KMT2APOLBPGR | |
| SCHEMBL6642118 | 0.67 | TP53 (0.51) | MEN1KMT2A | |
| SCHEMBL10607508 | 0.63 | CYSLTR1 (0.71) | FFAR1MAOB | |
| SCHEMBL6635484 | 0.63 | MAOB (0.43) | GRM5MEN1KMT2APGRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100795-B1 | DISUBSTITUTED BICYCLIC HETEROCYCLES HAVING, IN PARTICULAR, A THROMBIN INHIBITIVE EFFECT | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-06-09 | — | — | EP | disclosed |
| US-6121308-A | INDOLE AND BENZIMIDAZOLE ANTITHROMBOTIC COMPOUNDS, SUCH AS 1-METHYL-2-(N-(4-AMIDINOPHENYL)-AMINOMETHYL)-5-(N-(HYDROXYCARBONYLMETHYL) -QUINOLINE-8-SULPHONYLAMINO)-INDOLE | BOEHRINGER INGELHEIM KG (DE) | 2000-09-19 | — | — | US | disclosed |