Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636404 | 0.67 | ACHE (0.40) | TP53SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL6304622 | 0.65 | MC4R (0.43) | SMN1; SMN2CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7508681 | 0.61 | KMT2A (0.57) | MAPTGRM5LMNA | |
| SCHEMBL7508672 | 0.60 | ACSS2 (0.45) | MAPTGRM5HPGDMAPK1NPC1 | |
| SCHEMBL920141 | 0.59 | TDP1 (0.60) | TP53SMN1; SMN2MAPTMAPK1TSHR | |
| SCHEMBL1244396 | 0.58 | TDP1 (0.48) | HPGDMAPK1TSHRTDP1 | |
| SCHEMBL1614766 | 0.58 | SMN1; SMN2 (0.52) | TP53SMN1; SMN2MAPTHPGDCYP1A2 | |
| SCHEMBL13677280 | 0.57 | ACSS2 (0.53) | TP53SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL15063453 | 0.57 | TP53 (0.48) | TP53SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL10177398 | 0.57 | MAPT (0.51) | SMN1; SMN2MAPTHPGDCNR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-B1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORP (US) | 2004-09-29 | — | — | EP | claimed |