Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2476143 | 0.80 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTSMN1; SMN2NAMPT | |
| SCHEMBL693163 | 0.76 | MAPT (0.50) | ALDH1A1MAPTGPR119KMT2ANAMPT | |
| SCHEMBL2483206 | 0.75 | USP2 (0.39) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL31349154 | 0.75 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL18294 | 0.73 | USP2 (0.69) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL698803 | 0.73 | USP2 (0.69) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL5573222 | 0.72 | MAPT (0.76) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL2479566 | 0.72 | SMO (0.37) | MAPTSMN1; SMN2MEN1KMT2ACYP2C19 | |
| SCHEMBL26353773 | 0.72 | LMNA (0.41) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 | |
| SCHEMBL5683429 | 0.71 | MAPT (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | claimed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | claimed |
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |