Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29376241 | 0.89 | POLB (0.50) | POLBMAPK1ATMRAB9ADGAT1 | |
| SCHEMBL5393 | 0.89 | POLB (0.50) | POLBMAPK1ATMRAB9ADGAT1 | |
| SCHEMBL1226224 | 0.89 | POLB (0.50) | POLBMAPK1ATMRAB9ADGAT1 | |
| Phosphine SCHEMBL30259325 | 0.88 | POLB (0.48) | POLBMAPK1ATMRAB9ANPC1 | |
| Water SCHEMBL1042885 | 0.88 | POLB (0.48) | POLBMAPK1ATMRAB9ANPC1 | |
| Water SCHEMBL29441712 | 0.88 | POLB (0.48) | POLBMAPK1ATMRAB9ANPC1 | |
| SCHEMBL1012471 | 0.84 | POLB (1.00) | POLBMAPK1ATMRAB9ADGAT1 | |
| SCHEMBL3672275 | 0.84 | POLB (1.00) | POLBMAPK1ATMRAB9ADGAT1 | |
| SCHEMBL184 | 0.84 | POLB (1.00) | POLBMAPK1ATMRAB9ADGAT1 | |
| Phosphine SCHEMBL23702726 | 0.82 | POLB (0.95) | POLBMAPK1ATMRAB9ADGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190085026-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | Laurus Labs Ltd. (IN) | 2019-03-21 | — | — | US | claimed |
| EP-0997465-B1 | Azaindole derivatives and their use as antithrombotic agents | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0973517-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6359136-B1 | AZAINDOLE COMPOUND | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |
| US-6288105-B1 | COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |
| US-6265416-B1 | ANTICOAGULANTS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| EP-0997465-A1 | Azaindole derivatives and their use as antithrombotic agents | ELI LILLY AND COMPANY (US) | 2000-05-03 | — | — | EP | disclosed |
| EP-0973517-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998048794-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190085026-A1 | AN IMPROVED PROCESSES FOR THE PREPARATION OF CARFILZOMIB OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | PRCP, SF3B5, GBA1 | POLB 4327/4885MAPK1 1899/4885ATM 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.