Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.33 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.33 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | AKT2 | P31751 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222 | 0.91 | ABCC3 (0.34) | OPRM1BRD4ABCC3ABCC4ABCB11 | |
| SCHEMBL4089 | 0.84 | BRD4 (0.39) | GAABRD4ABCC3ABCC4ABCB11 | |
| SCHEMBL14648 | 0.78 | LPAR1 (0.44) | GAAOPRM1BRD4ABCC3ABCC4 | |
| SCHEMBL6642 | 0.77 | LPAR1 (0.39) | GAAOPRM1BRD4ABCC3ABCC4 | |
| SCHEMBL6411 | 0.76 | BRD4 (0.33) | BRD4ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6153 | 0.75 | GAA (0.36) | GAABRD4ABCC3ABCC4ABCB11 | |
| SCHEMBL4790 | 0.75 | BRD4 (0.34) | BRD4ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL4183 | 0.75 | GAA (0.42) | GAABRD4ABCC3ABCC4ABCB11 | |
| SCHEMBL2761257 | 0.74 | MAPT (0.37) | GAAMAPTHPGD | |
| SCHEMBL7532 | 0.74 | ALOX5 (0.35) | GAABRD4CYP2C9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |