Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SLC26A6 | Q9BXS9 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.32 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.32 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.32 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7234 | 0.90 | LPAR1 (0.34) | BRD4ALDH1A1ALOX5ALOX5APLPAR1 | |
| SCHEMBL7632 | 0.89 | KMT2A (0.38) | GAAALDH1A1MAPTP2RX7 | |
| SCHEMBL6445 | 0.89 | CHRM1 (0.36) | GAASLC26A6RAB9AALDH1A1ALOX5 | |
| SCHEMBL1559 | 0.88 | RAB9A (0.39) | GAARAB9AALDH1A1LPAR1ABCC3 | |
| SCHEMBL6765 | 0.87 | BRD4 (0.33) | GAASLC26A6BRD4ALDH1A1ALOX5 | |
| SCHEMBL7532 | 0.84 | ALOX5 (0.35) | GAABRD4ALDH1A1ALOX5CYP2C9 | |
| SCHEMBL7572 | 0.83 | SLC26A6 (0.36) | GAASLC26A6BRD4ALDH1A1ALOX5 | |
| SCHEMBL6236 | 0.83 | GAA (0.34) | GAABRD4LPAR1ABCC3ABCC4 | |
| SCHEMBL2214 | 0.83 | LPAR1 (0.45) | ALDH1A1ALOX5ALOX5APLPAR1ABCC3 | |
| SCHEMBL11897090 | 0.82 | HDAC1 (0.36) | RAB9AALDH1A1CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |