Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL710433 | 0.80 | NPC1 (0.71) | MAPK1NPC1MAPTKDM4ERAB9A | |
| SCHEMBL5885621 | 0.80 | TLR9 (0.53) | MAPK1NPC1MAPTKDM4ERAB9A | |
| SCHEMBL5885440 | 0.78 | ALDH1A1 (0.60) | MAPTKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL28617539 | 0.74 | HTT (0.42) | NPC1MAPTKDM4ERAB9AALDH1A1 | |
| SCHEMBL6639468 | 0.74 | PDGFRB (0.51) | NPC1KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL8502224 | 0.74 | ALDH1A1 (0.74) | MAPK1NPC1MAPTKDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL8499941 | 0.73 | ALDH1A1 (0.72) | MAPK1NPC1MAPTKDM4ERAB9A | |
| SCHEMBL17979213 | 0.72 | FGFR3 (0.56) | MAPK1KDR | |
| SCHEMBL28860564 | 0.72 | MAPK1 (0.54) | MAPK1NPC1MAPTKDM4ERAB9A | |
| SCHEMBL28165865 | 0.72 | MAPT (0.61) | MAPK1NPC1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427421-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | Amgen Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003018021-A1 | 2,4-DISUBSTITUTED PYRIMIDINYL DERIVATIVES FOR USE AS ANTICANCER AGENTS | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |