Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6639468 | 0.84 | PDGFRB (0.51) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL6643284 | 0.78 | MAPK1 (0.52) | ALDH1A1KDM4EL3MBTL1KMT2AMEN1 | |
| SCHEMBL30696080 | 0.78 | KDM4E (0.92) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL6339578 | 0.78 | KDM4E (0.92) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL17184372 | 0.77 | MAPK14 (0.51) | KDM4EL3MBTL1LMNATDP1MAPK14 | |
| SCHEMBL15987437 | 0.77 | KDM4E (0.50) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL21852751 | 0.75 | ALDH1A1 (0.67) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL15056743 | 0.75 | KDM4E (1.00) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL2867767 | 0.75 | MAPK14 (0.69) | ALDH1A1KDM4EL3MBTL1LMNANPSR1 | |
| SCHEMBL193961 | 0.74 | KMT2A (0.34) | ALDH1A1KDM4EL3MBTL1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115617-B2 | Amino-substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2006-10-03 | — | — | US | disclosed |
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |