Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16026511 | 0.68 | ALDH1A1 (0.46) | ALDH1A1GAAMAPTTSHRALOX15 | |
| SCHEMBL17622338 | 0.68 | ALOX15 (0.48) | SRD5A1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL15361901 | 0.67 | KMT2A (0.59) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL5715497 | 0.65 | ALDH1A1 (0.53) | SRD5A1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL19117986 | 0.65 | SRD5A1 (0.56) | SRD5A1NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL29652020 | 0.64 | GSK3B (0.50) | SRD5A1NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL12683737 | 0.64 | ALDH1A1 (0.49) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL2699695 | 0.64 | POLB (0.47) | NPC1RAB9AALDH1A1MAPTKMT2A | |
| SCHEMBL25026229 | 0.63 | ALDH1A1 (0.55) | SRD5A1ALDH1A1TSHRALOX15BRCA1 | |
| SCHEMBL17622337 | 0.63 | ALOX15 (0.46) | SRD5A1NPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1197485-B1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| US-6696469-B2 | FOR TREATMENT OF DISEASES OR PATHOLOGICAL CONDITIONS IN WHICH ENDOTHELIAL DYSFUNCTION IS KNOWN; ATHEROSCLEROSIS, DYSLIPIDAEMIA, DIABETES | LES LABORATOIRES SERVIER (FR) | 2004-02-24 | — | — | US | disclosed |
| US-20020065419-A1 | Cyclobutenedione compounds | LES LABORATOIRES SERVIER (FR) | 2002-05-30 | — | — | US | disclosed |
| EP-1197485-A1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | Les Laboratoires Servier (FR) | 2002-04-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065419-A1 | Cyclobutenedione compounds | NR3C2, NR5A1, CYP11B1 | SRD5A1 30/4885NPC1 3121/4885RAB9A 3079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.