Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081885 | 0.85 | MAPT (0.55) | GSK3BMAPTLMNATP53MAPK1 | |
| SCHEMBL15345494 | 0.84 | DRD3 (0.50) | GSK3BMAPTLMNATP53MAPK1 | |
| SCHEMBL5715497 | 0.76 | ALDH1A1 (0.53) | MAPTNOTUMLMNATP53MAPK1 | |
| SCHEMBL23864705 | 0.74 | DRD2 (0.47) | MAPTNOTUMALDH1A1ROCK1SMN1; SMN2 | |
| SCHEMBL3905172 | 0.72 | ALDH1A1 (0.53) | MAPTNOTUMLMNATP53MAPK1 | |
| SCHEMBL29542545 | 0.72 | ALDH1A1 (0.53) | MAPTNOTUMLMNATP53MAPK1 | |
| SCHEMBL11880068 | 0.72 | ROCK1 (0.50) | MAPTNOTUMMAPK1MEN1KMT2A | |
| SCHEMBL5064225 | 0.71 | ALDH1A1 (0.52) | GSK3BMAPTLMNATP53MAPK1 | |
| SCHEMBL30874673 | 0.71 | ALDH1A1 (0.52) | MAPTLMNATP53MAPK1MEN1 | |
| SCHEMBL9215081 | 0.71 | MEN1 (0.54) | MAPTNOTUMLMNATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539086-A | Method for synthesizing diclofenac sodium | 复旦大学 | 2022-05-27 | — | — | CN | claimed |
| CN-114516813-A | Continuous flow preparation method of diclofenac sodium | 复旦大学 | 2022-05-20 | — | — | CN | claimed |
| CN-113429308-B | Synthesis process of diclofenac sodium | 安徽普利药业有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-114539086-A | Method for synthesizing diclofenac sodium | 复旦大学 | 2022-05-27 | — | — | CN | disclosed |
| CN-114539086-A | Method for synthesizing diclofenac sodium | 复旦大学 | 2022-05-27 | — | — | CN | disclosed |
| CN-114516813-A | Continuous flow preparation method of diclofenac sodium | 复旦大学 | 2022-05-20 | — | — | CN | disclosed |