Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PRF1 | P14222 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28566639 | 0.81 | CLK4 (0.42) | NOS2MAPTKDM4EMAPK1NOS3 | |
| SCHEMBL5597800 | 0.77 | NOS2 (0.37) | NOS2TLR8LMNAMEN1ALDH1A1 | |
| SCHEMBL3291513 | 0.71 | TLR8 (0.36) | TLR8 | |
| SCHEMBL30241135 | 0.71 | PTGDR2 (0.40) | KDM4ETLR8MEN1ALDH1A1KMT2A | |
| SCHEMBL14301805 | 0.68 | CYP1A2 (0.44) | MAPTKDM4EMAPK1LMNAPOLB | |
| SCHEMBL4978700 | 0.65 | CLK4 (0.42) | KDM4ETLR8 | |
| SCHEMBL14958066 | 0.65 | PDE3B (0.35) | MAPTKDM4EMAPK1LMNAPOLB | |
| SCHEMBL16739927 | 0.65 | NOS3 (0.31) | NOS2NOS3NOS1ALDH1A1 | |
| SCHEMBL3294049 | 0.65 | KMT2A (0.35) | MAPTKDM4EMAPK1LMNAPOLB | |
| SCHEMBL14957158 | 0.64 | PDE3B (0.34) | MAPTKDM4EMAPK1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003074515-A1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-09-12 | — | — | WO | disclosed |