Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 7/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643557 | 0.84 | HTR1A (0.42) | HTR1AMAOBSLC6A4DRD2HTR2A | |
| SCHEMBL6642667 | 0.80 | SIGMAR1 (0.44) | HTR1ASIGMAR1MAOBDRD2HTR2A | |
| SCHEMBL5568960 | 0.77 | NPC1 (0.55) | MAOBDRD2HTR2ADRD3SMN1; SMN2 | |
| SCHEMBL6642758 | 0.76 | KDM4E (0.48) | HTR1ASIGMAR1MAOBSLC6A4DRD2 | |
| SCHEMBL6641570 | 0.76 | DRD2 (0.45) | HTR1ASIGMAR1MAOBSLC6A4DRD2 | |
| SCHEMBL5563913 | 0.75 | TSHR (0.57) | MAOBDRD2HTR2ADRD3SMN1; SMN2 | |
| SCHEMBL6641567 | 0.74 | DRD2 (0.47) | HTR1ASIGMAR1MAOBDRD2HTR2A | |
| SCHEMBL5568634 | 0.73 | NPC1 (0.53) | MAOBDRD2HTR2ADRD3SMN1; SMN2 | |
| SCHEMBL6214213 | 0.72 | DRD2 (0.50) | HTR1ASIGMAR1SLC6A4GPR6DRD2 | |
| SCHEMBL5569638 | 0.71 | TSHR (0.54) | MAOBDRD2HTR2ADRD3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1197485-B1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1197485-A1 | Cyclobuten-dione derivatives for use in the treatment of artherosclerosis | Les Laboratoires Servier (FR) | 2002-04-17 | — | — | EP | disclosed |