Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6646005 | 0.81 | ADRA1B (0.76) | BRD4GAAKDM4EALDH1A1ADRA1B | |
| SCHEMBL4716700 | 0.77 | KDM5B (0.57) | ADRA1BCDK2MAPTCYP2A6 | |
| SCHEMBL4716704 | 0.77 | KDM5B (0.57) | ADRA1BCDK2MAPTCYP2A6 | |
| SCHEMBL6650055 | 0.76 | GAA (0.67) | BRD4GAAKDM4EALDH1A1ADRA1B | |
| SCHEMBL6651229 | 0.74 | GAA (0.71) | BRD4GAAKDM4EALDH1A1HPGD | |
| SCHEMBL16424694 | 0.74 | BRD4 (1.00) | BRD4GAAKDM4EALDH1A1HPGD | |
| SCHEMBL5167461 | 0.72 | IDO1 (0.46) | GAAKDM4EALDH1A1MAPK1IDO1 | |
| SCHEMBL6645240 | 0.71 | GAA (0.51) | BRD4GAAKDM4EALDH1A1HPGD | |
| SCHEMBL12781599 | 0.70 | ADRA1B (0.71) | BRD4GAAKDM4EALDH1A1ADRA1B | |
| SCHEMBL997742 | 0.69 | GAA (0.59) | BRD4GAAKDM4EALDH1A1ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | claimed |
| US-6638933-B2 | Analgesics | GRUENENTHAL GMBH (DE) | 2003-10-28 | — | — | US | claimed |
| JP-2003511451-A | — | — | 2003-03-25 | — | — | JP | claimed |
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | GRUENENTHAL GMBH | 2003-01-23 | — | — | US | claimed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| EP-1218382-B1 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| US-6638933-B2 | Analgesics | GRUENENTHAL GMBH (DE) | 2003-10-28 | — | — | US | disclosed |
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | GRUENENTHAL GMBH | 2003-01-23 | — | — | US | disclosed |
| EP-1218382-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001027111-A2 | BICYCLIC IMIDAZO-3-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018032-A1 | Bicyclic imidazo-3-yl-amine derivatives | OPRK1, IPO4, GRIN3A | BRD4 60/4885GAA 3278/4885KDM4E 2957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.