Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.49 |
| ▸ | PDE2A | O00408 | 8/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040798 | 0.78 | LCK (0.37) | LCK | |
| SCHEMBL4042246 | 0.75 | LCK (0.35) | LCK | |
| SCHEMBL31026828 | 0.73 | CHEK1 (0.34) | LCK | |
| SCHEMBL31060458 | 0.72 | LCK (0.40) | LCK | |
| SCHEMBL6645545 | 0.69 | PDE10A (0.38) | PDE10APDE2ALCK | |
| SCHEMBL31137728 | 0.67 | LCK (0.58) | LCK | |
| SCHEMBL13806808 | 0.66 | PDE10A (0.60) | PDE10APDE2APDE5APDE7APDE3A | |
| SCHEMBL8404003 | 0.66 | ADK (0.37) | LCK | |
| SCHEMBL4112388 | 0.65 | PDE10A (0.79) | PDE10APDE2APDE5APDE7APDE3A | |
| SCHEMBL4040692 | 0.64 | LCK (0.31) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066286-A4 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-02-11 | — | — | EP | disclosed |
| EP-1066286-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999045009-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOPYRAZINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-10 | — | — | WO | disclosed |